S.E.M.I.: Side Effects May Include...
By: Two Horn Unicorn
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S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.
- Platforms
- PC (Microsoft Windows)
- Game modes
- Co-operativeMultiplayerSingle player
- Perspectives
- Third person
- Engines
- Unreal Engine 5
- Keywords
- action combataction platformeraction roguelikecrazyescape gamefunnylogic puzzleonline coopphysicsphysics puzzlespuzzle platformerragdoll physics
- Languages
- Chinese (Simplified) · Interface, AudioDutch · Interface, AudioEnglish · Audio, InterfaceEnglish (UK) · Audio, InterfaceFrench · Audio, InterfaceGerman · InterfaceJapanese · Interface, AudioPortuguese (Brazil) · Audio, InterfaceRussian · Interface, AudioSpanish (Spain) · Audio, Interface
- Multiplayer
- Online co-op
Complete release history (2)
PC (Microsoft Windows) · Nov 20, 2025
Worldwide · Exact date · Early access · IGDB
PC (Microsoft Windows) · Jan 23, 2026
Worldwide · Exact date · Full release · IGDB
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